COVID-19 intranasal vaccines: current progress, advantages, prospects, and challengesCOVID-19 비강내 백신: 현재 진행 상황, 이점, 전망 및 과제Review Published on 2022-11-302022-09-12 Journal: Human vaccines & immunotherapeutics [Category] MERS, SARS, 진단, [키워드] added Administered administration Antibody Response Cell-mediated immunity cellular immunity country COVID-19 COVID-19 pandemic COVID-19 vaccine disease highlight immune response Immunity induce injected injection intramuscular intranasal intranasal vaccine limit MOST mucosal mucosal immunity. Multiple nasal pandemic Prevent Protective Replication robust SARS-CoV-2 SARS-CoV-2 vaccine secretory IgA shown stimulate Vaccine Vaccines virus infection virus transmission [DOI] 10.1080/21645515.2022.2045853 PMC 바로가기 [Article Type] Review
More tools for our toolkit: The application of HEL-299 cells and dsRNA-nanoparticles to study human coronaviruses in vitroArticle Published on 2022-11-012022-11-15 Journal: Virus research [Category] SARS, 치료법, 치료제, [키워드] ACE2 receptor Analysis Antiviral antiviral genes antiviral response antiviral therapy can be used Cell cell line cells Combination competent Complete coronavirus Coronavirus replication CXCL10 cytidylic acid double-stranded expand fibroblast Gene Expression HCoV-229E HCoV-NL63 help Human human coronavirus human coronaviruses human lung IFN IFNs IFNβ in vitro increase in inducer Infection inhibit innate immune interferons ISG15 limit MERS-CoV Nanoparticles Pathogens Poly I:C. post infection PROTECT provided required SARS-CoV-2 SARS-CoV-2 pandemic stimulate translated Treatment Type I IFN type I interferon virus production were infected while [DOI] 10.1016/j.virusres.2022.198925 PMC 바로가기
Galectin-3 binding protein stimulated IL-6 expression is impeded by antibody intervention in SARS-CoV-2 susceptible cell linesArticle Published on 2022-10-112022-11-15 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 진단, [키워드] Activation affected antibody binding cell line cell types Colon contribute COVID-19 COVID-19 patients described disease epithelial expression galectin-3 global pandemic identify IL-6 IL-6 expression inflammatory cells Intervention lung epithelial marker monoclonal antibody pathophysiology pro-inflammatory cytokine Protein receptor Research SARS-CoV-2 severe cases severe COVID-19 patients severe disease severity stimulate stimulated susceptible cell the cytokine storm therapeutic targets Treatment was reduced [DOI] 10.1038/s41598-022-20852-x PMC 바로가기
Multiple sclerosis relapse after COVID-19 vaccination: A case report-based systematic reviewReview article Published on 2022-10-012022-10-05 Journal: Journal of clinical neuroscience : official journa [Category] 진단, [키워드] Abstract benefit booster dose Case report case sery concern COVID-19 COVID-19 vaccination COVID-19 vaccine disease dosage Efficacy eligible Exacerbation FIVE include Infection Multiple multiple sclerosis Patient patients Relapse reported Result risk searched second dose Side effects stimulate Symptom systematic review vaccination vaccination against COVID-19 Vaccine weakness Web of Science [DOI] 10.1016/j.jocn.2022.08.012 [Article Type] Review article
Virtual screening and molecular dynamics simulation for identification of natural antiviral agents targeting SARS-CoV-2 NSP10Short communication Published on 2022-10-012022-10-05 Journal: Biochemical and Biophysical Research Communication [Category] COVID19(2023년), SARS, 치료제, [키워드] Analysis Antiviral agents binding binding energy calculated Candidates Complexes Compound COVID-19 docking enzymatic activity global pandemic inhibitor Interaction molecular dynamics Molecular dynamics simulation natural antiviral New nsp10 Protein RNA replication SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 viral selected stimulate suggested Vaccine Vaccine development Variation Virtual screening was performed ZINC database [DOI] 10.1016/j.bbrc.2022.08.029 [Article Type] Short communication
Could Endogenous Glucocorticoids Influence SARS-CoV-2 Infectivity?Article Published on 2022-09-212022-11-15 Journal: Cells [Category] SARS, 변종, 치료제, [키워드] ACE2 ACE2 (angiotensin converting enzyme 2) Affect alteration analogues Antiviral component conformational coronavirus coronavirus diseases cortisol COVID-19 Deleterious Dexamethasone endogenous enzyme glucocorticoid Glucocorticoids groups Host Immunological disorders Infection influence inhibit SARS-CoV-2 Innate immunity Interaction mechanism outcome pathogen produced PROTECT Protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor Signal transduction spike Spike protein spike protein. stimulate subunit surface protein target cells variant [DOI] 10.3390/cells11192955 PMC 바로가기
Evaluating the immunogenicity of gold nanoparticles conjugated RBD with Freund’s adjuvant as a potential vaccine against SARS-CoV-2Article Published on 2022-09-012022-11-15 Journal: Microbial pathogenesis [Category] COVID19(2023년), SARS, 진단, [키워드] adjuvant Antigen assays BALB/c mice boost candidate candidate vaccine cell-mediated immune response cell-mediated response cloned COVID-19 COVID-19 pandemic COVID-19 vaccine cytokine E. coli ENhance evaluated Evaluating examined expressed Freund's adjuvant global pandemic gold Gold nanoparticle Gold nanoparticles Health Host humoral Humoral immunity Humoral response IFN-γ IgG IgM IgM and IgG immune immune response immune system Immunogenic proteins Incomplete injected interval long-term immune response marker material Nano-vaccines outcome pandemic purified RBD RBD antigen RBD protein repeated SARS-CoV-2 SARS-CoV-2. significantly higher stimulate structural protein the RBD protein treatment group Vaccine while [DOI] 10.1016/j.micpath.2022.105687 PMC 바로가기
Preliminary investigation of gene expression levels of PAPP-A, STC-2, and HIF-1α in SARS-Cov-2 infected patientsArticle Published on 2022-09-012022-11-16 Journal: Molecular biology reports [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] alteration Analysis Clinical data condition COVID-19 COVID-19 infection COVID-19 patients cytokine Cytokine storm demonstrated determine evaluated expression extracted RNA Gene Expression gene expression level gene expression pattern healthy individual HIF-1α individuals induce infected patient Infection influence Laboratory material molecular mRNA expression Other pandemic PAPP-A Patient patients with COVID-19 Peripheral blood positive correlation pro-inflammatory molecules Prognosis Real-time PCR SARS-CoV-2 Severe patient STC-2. stimulate target was used [DOI] 10.1007/s11033-022-07710-9 PMC 바로가기
Squalene in oil-based adjuvant improves the immunogenicity of SARS-CoV-2 RBD and confirms safety in animal models오일 기반 보조제의 스쿠알렌은 SARS-CoV-2 RBD의 면역원성을 개선하고 동물 모델에서 안전성을 확인합니다Article Published on 2022-08-232022-09-11 Journal: PLoS ONE [Category] SARS, 변종, 진단, 치료기술, [키워드] accelerated adjuvant Analysis animal model assays binding Cellular immune response Chromatography conditions COVID-19 demonstrated determine determined by elicited ELISA etiologic agent evaluated expressed flow cytometry Formulation hamsters histopathological humoral immune immunization immunogenicity IMPROVE insect cell insect cells kidney lead liver Lungs mice Neutralizing antibodies neutralizing antibody pandemic Protein purified RBD of SARS-CoV-2 RBD protein receptor Safe SARS-CoV-2 SARS-CoV-2 RBD sera shown squalene stimulate sub-unit vaccine the Spike Vaccine vaccine candidate variant virus water [DOI] 10.1371/journal.pone.0269823 PMC 바로가기 [Article Type] Article
Applying high throughput and comprehensive immunoinformatics approaches to design a trivalent subunit vaccine for induction of immune response against emerging human coronaviruses SARS-CoV, MERS-CoV and SARS-CoV-2새로운 인간 코로나바이러스 SARS-CoV, MERS-CoV 및 SARS-CoV-2에 대한 면역 반응 유도를 위한 3가 서브유닛 백신을 설계하기 위해 높은 처리량 및 포괄적인 면역정보학 접근법 적용Article Published on 2022-08-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 치료법, [키워드] acute respiratory syndrome added adjuvant against SARS-CoV analysis Antigen antigens applied Applying approach approach B-cell binding affinity codon optimization complex conducted coronavirus disease Coronavirus disease 2019 CoV COVID-19 CoVs CTL defensin demonstrated disease docking epitope Epitopes facilitate HLA HTL HTLs human coronavirus IEDB IFN IFN-γ immune response immune responses immunogenic immunoinformatics In silico cloning increased expression kDa MDs membrane MERS MERS-CoV MERS‐CoV MHC I Middle East Middle East respiratory syndrome molecular dynamics Molecular dynamics simulation molecular weight molecule Multi-epitope vaccine non-allergenic non-structural protein nucleocapsid PADRE Pan predicted Protein responses SARS-CoV SARS-CoV-2 SARS‐CoV secondary selected epitope sequence sequences Severe acute respiratory syndrome stability stimulate Structure subunit Subunit vaccine Subunit vaccine. syndrome T lymphocyte TAT the vaccine trivalent Vaccine was used β-defensin [DOI] 10.1080/07391102.2021.1876774 PMC 바로가기 [Article Type] Article